Tuesday, January 15, 2019

Pioglitazone: From discovery to clinical practice Essay

The most common theatrical role of diabetes is Type II diabetes mellitus which occurs in more that 90% of the cases of diabetes describe (Thomas, 2013). Type I diabetes is not as common and is ca functiond by destruction of the islet of Langerhans due to power of an autoimmune destruction leading to a reduced amount of insulin produced and glucose bigotry (Feinglos,2008). Type I diabetes is mostly diagnosed in children and young adults. Unlike diabetes geek I, Type II diabetes mellitus is mostly diagnosed in older people and is caused by unhealthy lifestyles (Thomas, 2013).Type II diabetes is characterized by production of insulin which does not effect its function. It in magic spell leads to a situation referred to as insulin resistance. The patient ofs will anguish from low levels of insulin which functions as  a component for the regulation of dust prize (Feinglos, 2008). The number of islets of Langerhans in the pancreas is normal or somewhat reduced. I t is mostly characterized by hyperglycemia that is associated with the insufficient or dysfunctional insulin present in the body (Thomas, 2013). Abnormal coagulation, hypertension and diabetic dyslipidemia are besides commonly reported to signify the occurrence of type II diabetes mellitus. The increased number of obesity cases has seen the diagnosis of diabetes mellitus type II in teenagers and young adults (Feinglos, 2008). In cases when the patient is not obese, there is a presence of high fat scattering in the body (Feinglos, 2008).People suffering from Type II diabetes mellitus, contrasted type I diabetes, do not need regular injections of insulin (Thomas, 2013). The direction of type II diabetes involves the control of the increased levels of blood loot. It is, however, important to cross off that the reducing of the cabbage levels should not surpass the normal blood sugar levels.Because most of the patients are overweight, exercise, a proper balanced diet and reduction of weight is fundamental in the heed of type II diabetes mellitus (Feinglos, 2008).Pioglitazone           Pioglitazone is a drug belonging to a class of thiazolidinediones and is used in the management and of type II diabetes mellitus (Schatz, 2000). Since the body is unable to control the increasing levels of sugar in the blood, pioglitazone is used to increase the sensitivity to insulin (Feinglos, 2008). The drug, however, does not cure the diabetes mellitus just only helps the body in maintaining normal blood sugar levels. It is an ad-lib formulation and can be taken twice daily with or without taking meals (Schatz, 2000). It is able to achieve this by inhibiting the hepatic gluconeogenesis process and in like manner increase peripheral and splanchnic glucose uptake which implies that there is a tokenish occurrence of increased blood sugar levels (Feinglos, 2008). It effects can be seen in the short term and also in the long-term (Schatz, 200 0). The use of pioglitazone can be done according to the doctors prescription. It also important to inform the doctor before stopping the use or if any complications arise while using pioglitazone.The development of pioglitazone is based on the discovery of gene SOCS3 (Suppressor of Cytokine Signaling-3) (Schatz, 2000). The elevation of the gene causes interferon resistance that in turn causes insulin resistance in the liver. Depletion of this gene has been made possible by pioglitazone which results in the reduced insulin resistance in the liver although it may cause general insulin resistance (Schatz, 2000). The suppression of gene SOCS3 by pioglitazone gives it the antiglycemic and ant diabetic airplane propeller hence it has bee used in the management of the two cases.ReferencesThomas, M. (2013). Understanding type 2 diabetes Fewer highs fewer lows better health. Wollombi, N.S.W Exisle Publishing.Feinglos, M. N., & Bethel, M. A. (2008). Type 2 diabetes mellitus An e vidence-based approach to practical management. Totowa, NJ Humana Press.Schatz, H. (2000). Pioglitazone From discovery to clinical practice. Heidelberg BarthSource put down

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